* There is a considerable need for improved treatments for individuals with NT1, which is caused by the loss of orexin-producing neurons in the brain. Population for Testing doi:10.1164/ajrccm.162.4.9911073, Guimaraes C, Martins MV, Vaz Rodrigues L, Teixeira F, Moutinho Dos Santos J (2012) Epworth Sleepiness Scale in obstructive sleep apnea syndrome an underestimated subjective scale. STOP, THAT and One Hundred Other Sleep Scales pp 209210Cite as, 2 111, 03048, Cottbus, Deutschland, Habersaathstrae 38e, 10115, Berlin, Deutschland, Klinik und Poliklinik fr Hals-Nasen-Ohren-Heilkunde, Universittsklinikum Regensburg, Franz-Josef-Strau-Allee11, 93053, Regensburg, Deutschland, Institut fr Medizinische Epidemiologie, Biometrie und Informatik, Martin-Luther-Universitt Halle-Wittenberg, Magdeburger Strae8, 06112, Halle (Saale), Deutschland, Klinik und Poliklinik fr Hals-, Nasen-, Ohrenkrankheiten, Kopf- und Halschirurgie, Universittsmedizin Greifswald, Sauerbruchstrasse, 17475, Greifswald, Deutschland, Klinik und Poliklinik fr Hals-Nasen-Ohren-Heilkunde, Kopf- und Halschirurgie, Martin-Luther-Universitt Halle-Wittenberg, Ernst-Grube-Strae40, 01620, Halle (Saale), Deutschland, You can also search for this author in The present study made use of already collected data, which means the study was not explicitly designed for its purpose. Portuguese]. The main aim of the present study was to investigate the validity and reliability of the KSS with electroencephalographic, behavioral and other subjective indicators of sleepiness. 2005;101:9438. Narcolepsy Fast Facts. The effects of sleep debt and monotonous work on sleepiness and performance during a 12-h dayshift. Am J Respir Crit Care Med 162(4 Pt 1):15121517. Not viewing the scales as ordinal and computing absolute differences regardless of closeness showed a significant difference across the 19 scale. Sleepiness in long distance truck driving: an ambulatory EEG study of night driving. To date, there are no studies examining whether these versions can be used interchangeably. The images or other third party material in this article are included in the articles Creative Commons licence, unless indicated otherwise in a credit line to the material. Sleep. MeSH . PubMed Central PMC 2012;46(4):4227. National Library of Medicine Part of Springer Nature. Significance: KSS ratings may be a useful proxy for EEG or behavioral indicators of sleepiness. Im Rahmen einer monozentrischen, prospektiven, nichtinterventionellen Beobachtungsstudie bei Patienten (n= 97) mit Verdacht auf schlafbezogene Atmungsstrungen wurde in zeitlichem Zusammenhang zur Polysomnographieuntersuchung und Therapie die Tagesschlfrigkeit erfasst. 9=very sleepy, great effort to keep awake, fighting sleep . Extended driving impairs nocturnal driving performances. and transmitted securely. Adapted from [9]. Relations Between Performance and Subjective Ratings of Sleepiness HHS Vulnerability Disclosure, Help Karolinska Scales of Personality (KSP) is a personality test. Int J Psychophysiol. For better understanding of the results the variation across time is illustrated in Fig. The Karolinska drowsiness test (KDT) was applied to construct physiological alertness scales and to validate them against such well-known instrument of subjective sleepiness assessment as the Karolinska sleepiness scale (KSS). Using the Karolinska Sleep Questionnaire to identify obstructive sleep apnea syndrome in a sleep clinic population Diagnostic accuracy of the apnea/snoring and sleepiness indices for OSAS was poor but could be improved by combining clinical and KSQ items. Bethesda, MD 20894, Web Policies Eur Arch Otorhinolaryngol 269(4):11431147. Ohayon MM. Google Scholar, Chica-Urzola HL, Escobar-Cordoba F, Eslava-Schmalbach J (2007) Validating the Epworth Sleepiness Scale (Validacion de la Escala de Somnolencia de Epworth). Comparing two versions of the Karolinska Sleepiness Scale (KSS) - Springer The answers are grouped into 15 scales: Psychic anxiety Somatic anxiety Muscular tension Psychasthenia Evaluation of the sleepy patient - Royal Australian College of General The PDSS was the only instrument considered reliable to assess EDS in Brazilian children and adolescents. Torbjrn kerstedt. 7=sleepy, but no effort to keep awake . Martin VP, Rouas JL, Micoulaud-Franchi JA, Philip P, Krajewski J. doi: 10.1371/journal.pone.0045987. This site needs JavaScript to work properly. The subjects were asked if certain symptoms of sleepiness had . The original scale (A) included labels on every second step (1, 3, 5, 7, and 9), that is, the uneven numbers. 1948;43(244):5724. The Karolinska Sleepiness Scale (KSS) is frequently used to study sleepiness in various contexts. OSAS was defined as apnea-hypopnea index 5 with symptoms of disease. and transmitted securely. This study was conducted as a single-center, randomized, double-blind, placebo- and active-controlled, crossover design in 20 sleep-deprived healthy male adults. Fontes de dados: 1968;70(4):21320. doi: 10.1111/jsr.13558. Karolinska Sleepiness Scale results generally reflected the results obtained on the MWT.Orexin has been identified as a master regulator of sleep-wake states, and these early results demonstrate that an OX2R agonist may reduce daytime sleepiness in NT1, where there is a loss of orexin, said Deborah Hartman, PhD, Global Program Lead, Takeda Neuroscience. Stanford Sleepiness Scale - Wikipedia Revisar sistematicamente a literatura sobre os instrumentos utilizados para avaliar a sonolncia diurna excessiva (SDE) em crianas e adolescentes brasileiros. The Stanford Sleepiness Scale (SSS), developed by William C. Dement and colleagues in 1972, is a one-item self-report questionnaire measuring levels of sleepiness throughout the day. Methods: Google Scholar. The instruments most frequently used were the Pediatric Daytime Sleepiness Scale (PDSS) and Karolinska Sleepiness Scale (KSS), but only PDSS was shown reliable to assess EDS in Brazilian children and adolescents. CAS The weighted Kappa values was K=0.73, with a 95% confidence interval of 0.650.83. The Karolinska sleepiness scale (KSS) is frequently used for evaluating subjective sleepiness. Sleep Sci. 2=0.45 (s.e=0.05, p<0.0001). They are probably less useful when administered while the patient is at the clinic; a measure would be more useful if it reflected sleepiness while driving or probed a more general 'trait', like degree of sleepiness. The https:// ensures that you are connecting to the https://doi.org/10.1007/s00106-016-0270-3, DOI: https://doi.org/10.1007/s00106-016-0270-3. Careers. 2018;67:5565. Google Scholar, Chung KF (2000) Use of the Epworth Sleepiness Scale in Chinese patients with obstructive sleep apnea and normal hospital employees. Felden P, Carniel JD, Andrade RD, Pelegrini A, Anacleto TS, Louzada FM. New Data Presented at World Sleep Congress Demonstrate Early Signs of Efficacy for TAK-925, a Selective Orexin Type-2 Receptor (OX2R) Agonist, in Patients with Narcolepsy Type 1. official website and that any information you provide is encrypted PDF Karolinska Sleepiness Scale (KSS) - Perelman School of Medicine at the Neither Takeda nor its management gives any assurances that the expectations expressed in these forward-looking statements will turn out to be correct, and actual results, performance or achievements could materially differ from expectations. Validation of the Karolinska sleepiness scale against performance and CAS Subjective sleepiness was assessed with the KSS every hour, starting at 08:00 (day 1). Psychiatry Res 200(23):795801. Results indicated that the two versions are highly correlated, do not have different response distributions on labeled and unlabeled steps, and that the distributions across all steps have a high level of correspondence (Kappa=0.73). The mean of methodological quality of studies was 16.11.9 points. Driver sleepinessevaluation of reaction time measurement as a secondary task. 6=some signs of sleepiness . The KSS consists of a 9-point scale, ranging from 1 for very alert to 9 for very sleepy, with 5 as neither alert nor sleepy. Unless otherwise specified, the reliability scores and values come from studies done with a United States population sample. Foram selecionados 16 artigos, nos quais se identificaram nove instrumentos distintos aplicados em 8.240 crianas e adolescentes das regies Sul, Sudeste, Centro-Oeste e Nordeste do Brasil. Unauthorized use of these marks is strictly prohibited. Bookshelf The answers are grouped into 15 scales: This page is not available in other languages. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). eCollection 2021. Kaida M, Takahashi T, kerstedt A, Nakata Y, Otsuka T, Haratani K, et al. The Epworth Sleepiness Scale (ESS) is frequently used to determine daytime sleepiness in patients with sleep-disordered breathing. Estimating adolescent sleep need using dose-response modeling. Gewidmet Prof. Dr. Wolfgang Pirsig, als Pionier der deutschen HNO-rztlichen Schlafmedizin. The Karolinska Sleepiness Scale (KSS) [2] has been widely used in studies of shiftwork [3], sleep deprivation [4], and driving [5]. 8600 Rockville Pike Am J Respir Crit Care Med 165(9):12171239, Zea-Sevilla MA, Martinez-Martin P (2014) Rating scales and questionnaires for assessment of sleep disorders in Parkinsons disease: what they inform about? : , , - Miley A, Kecklund G, kerstedt T. Comparing two versions of the Karolinska Sleepiness Scale (KSS). st8=diG;t2_(Nz$Yb9'#dEi_ doi:10.3233/NRE-141117, Maldonado CC, Bentley AJ, Mitchell D (2004) A pictorial sleepiness scale based on cartoon faces. Language links are at the top of the page across from the title. Countless innovations. -. We will continue to build strong partnerships with the scientific, medical and patient communities to maintain our focus on research and development of transformative therapies.TAK-925 has been awarded Sakigake designation by the Ministry of Health, Labour and Welfare in Japan, as well as Breakthrough Therapy and Orphan Drug Designations by the U.S. Food & Drug Administration.Takeda would like to thank all of the study participants who enrolled in these pioneering clinical studies. One vision. [3] Because it can be used to evaluate specific moments, the scale can be used repeatedly at different time intervals in a research study or for treatment intervention.[3]. Sleep Biol Rhythms. J Neural Transm 121(Suppl 1):3340. Instruments For Assessment Of Excessive Daytime Sleepiness In - PubMed Where can I find the Karolinska Sleep Questionnaire? Concluses: We are focusing on developing highly innovative medicines that contribute to making a difference in people's lives by advancing the frontier of new treatment options and leveraging our enhanced collaborative R&D engine and capabilities to create a robust, modality-diverse pipeline. Industrial Health, 45, 520526. Normative data on the diurnal pattern of the Karolinska sleepiness scale ratings and its relation to . However, since the KSS scale is ordered, a more appropriate method is to use Cohens weighted Kappa [12] which takes into account how close the rating in one version is to the rating in the other version. PLoS One. 2012;7(9):e45987. KSP measures the personality with a 135 item questionnaire with answers on a four-point Likert scale . Sleep and recovery in physicians on night call: a longitudinal field study. Nat Sci Sleep. official website and that any information you provide is encrypted Distribution of ratings of each scale value [19] for versions A and B. The values from version A and version B were also correlated for each individual across time points. -. Correspondence to Comparing two versions of the Karolinska Sleepiness Scale (KSS) 2008;6:23441. Kaida K, Akerstedt T, Kecklund G, Nilsson JP, Axelsson J. The meeting was held in Vancouver, Canada from September 20-25, 2019. Google Scholar. endstream endobj 18 0 obj <> endobj 19 0 obj <> endobj 20 0 obj <>stream Sleepiness affects a large part of the population and is usually increased in relation to shift work or disturbed sleep [1]. Dissociation of Subjective and Objective Alertness During Prolonged Wakefulness. Clin Neurophysiol. Before Version B had 77 ratings for values 1, 3, 5, 7, and 9 and 66 ratings for the ratings 2, 4, 6, and 8. Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. [8] added labels to the remaining four (even) steps. Karolinska and Stanford sleepiness scales are measures of state (immediate) sleepiness. It is sensitive to fluctuations. Keywords: The site is secure. Furthermore, the average variance explained was r Article The study also showed a reasonable correlation between the two versions across time. A total of 14 NT1 participants were enrolled in three sequential dose cohorts to evaluate the effect of TAK-925 on exploratory pharmacodynamic endpoints. 2006;59(1):7079. Sleepiness (Karolinska Sleepiness Scale, scale 1-9) was rated at six times a day for a working week and 2 days off (>90.000 ratings). Objectives: doi:10.1007/s11325-010-0343-6, Article Objetivo: A controlled intervention study on the effects of a very rapidly forward rotating shift system on sleep-wakefulness and well-being among young and elderly shift workers. When all scale values were compared the exact comparison showed a significant difference whereas the weighted one did not. Honda was a referring physician for the NT1 study and is under contract with Takeda as a consultant.About World Sleep 2019 Biennial CongressWorld Sleep 2019 is a worldwide forum of sleep professionals focused on advancing current medical and scientific thinking in sleep research. The Karolinska Sleepiness Scale (KSS) and the Stanford Sleepiness Scale (SSS) served as references for the detection of present sleepiness at three different measurement times (morning, noon, evening), prior to and following a diagnostic polysomnography night as well as after a continuous positive airway pressure (CPAP) titration night (9 Article Federal government websites often end in .gov or .mil. Os instrumentos utilizados com maior frequncia foram o Pediatric Daytime Sleepiness Scale (PDSS) e o Karolinska Sleepiness Scale (KSS), porm somente o questionrio PDSS apresentou valores de confiabilidade adequados para avaliar a SDE em crianas e adolescentes brasileiros. Adapted from [9]. Chronobiol Int 21(45):673690, Kribbs NB, Pack AI, Kline LR etal (1993) Effects of one night without nasal CPAP treatment on sleep and sleepiness in patients with obstructive sleep apnea. The experiment involved 8 measurement sessions per day for 3 consecutive days. Epub 2007 Apr 26. Please enable it to take advantage of the complete set of features! Sagaspe P, Taillard J, Akerstedt T, Bayon V, Espie S, Chaumet G, et al. Azmeh Shahid M.D . All rights reserved. doi:10.1016/j.brainresbull.2003.12.016, Czeisler CA, Duffy JF, Shanahan TL et al (1999) Stability, precision, and near-24-hour period of the human circadian pacemaker. 2014;23(3):24052. In each cohort, the evaluation was conducted in a randomized, double-blinded, placebo-controlled, two-way crossover fashion.Pharmacodynamic outcomes in NT1 patients included i) sleep latency in the Maintenance of Wakefulness Test (MWT), which was 40 minutes (mins) in duration and conducted four times at two-hour intervals during the nine-hour TAK-925 or placebo infusion and ii) the Karolinska Sleepiness Scale, which was done hourly before and during the infusion. Disclaimer. It was concluded that the two versions are quite similar. It should be emphasized that this not a measure of reliability as that should be based on simultaneous administration of the two versions. Profiles of Subjective Daytime Sleepiness through Cluster Analysis, Psychometric properties and accuracy of the European Portuguese version of the Pittsburgh Sleep Quality Index in clinical and non-clinical samples, Nonrestorative sleep scale: reliable and valid for the Chinese population, Validation of the sleep hygiene index for the elderly, Associations Between Intraindividual Variability in Sleep and Daily Positive Affect, https://doi.org/10.1007/s41105-017-0111-0, https://creativecommons.org/licenses/by/4.0/. CrossRef There was also a possibility that the distribution across all the individual values 19 would be affected by the labeling. 1 verifies this finding; the steps without labels in version A were not consistently less used than the corresponding labeled steps in version B. One weakness is the modest number of participants, which may have affected the analysis of the distribution of ratings. Thus, the value of version A at 08:00 was paired with the value at 09:00 of version B, etc. Psychol Bull. The Role of Sleep Patterns from Childhood to Adolescence in Vigilant Attention. Retrospectively, we combined six KSQ items (snoring, breathing cessations, disturbed sleep, etc.) Malheiros LEA, da Costa BGG, Lopes MVV, Chaput JP, Silva KS. However, it exists in two versions, one with labels on every other step (version A), and one with labels on every step (version B) on the 9-point scale. https://doi.org/10.1007/978-1-4419-9893-4_47, DOI: https://doi.org/10.1007/978-1-4419-9893-4_47. Takeda is aggressively pursuing multiple approaches to better understand the therapeutic potential of OX2R agonists across a range of indications. The average correlation between version A and version B was r=0.66 (s.e=0.04, p<0.0001). What is equally exciting is that we also saw wake-promoting effects in healthy individuals, who are presumed to have normal orexin levels. Unauthorized use of these marks is strictly prohibited. Drowsiness; Method; Ratings; Sleep deprivation. Google Scholar. doi:10.1164/ajrccm/147.5.1162, Kushida CA, Littner MR, Morgenthaler T etal (2005) Practice parameters for the indications for polysomnography and related procedures: an update for 2005. The Karolinska Sleepiness Scale (KSS) is frequently used to study sleepiness in various contexts. Miley, A.., Kecklund, G. & kerstedt, T. Comparing two versions of the Karolinska Sleepiness Scale (KSS). 2016 Mar-Apr;92(2):168-73. doi: 10.1016/j.jped.2015.05.008. CrossRef Any forward-looking statements in this document are based on the current assumptions and beliefs of Takeda in light of the information currently available to it. -, Galland BC, Short MA, Terrill P, Rigney G, Haszard JJ, Coussens S, et al. Diagnostic accuracy of the apnea/snoring and sleepiness indices for OSAS was poor but could be improved by combining clinical and KSQ items. sharing sensitive information, make sure youre on a federal Sugere-se que pesquisas futuras relacionadas SDE em crianas e adolescentes faam a validao no Brasil de outros instrumentos e apresentem os valores de consistncia interna. Siwalee Choilek, Akihiro Karashima, Mitsuyuki Nakao, Giuseppe Loddo, Luca Vignatelli, Federica Provini, Vladimir B. Dorokhov, Elena B. Yakunina, Arcady A. Putilov, Daniel Ruivo Marques, Ana Allen Gomes & Maria Helena Pinto de Azevedo, Ana Allen Gomes, Daniel Ruivo Marques, Vanda Clemente, Sleep and Biological Rhythms On this scale subjects indicate which level best reflects the psycho-physical sate experienced in the last 10 min. Methods. Clin Otolaryngol Allied Sci 24(3):239241, Philip P (2005) Sleepiness of occupational drivers. PubMed Karolinska Scales of Personality ( KSP) is a personality test. Alle beschriebenen Untersuchungen am Menschen wurden mit Zustimmung der zustndigen Ethik-Kommission, im Einklang mit nationalem Recht sowie gem der Deklaration von Helsinki von 1975 (in der aktuellen, berarbeiteten Fassung) durchgefhrt. Die Epworth-Schlfrigkeits-Skala (ESS) ist ein hufig benutztes Messinstrument, um das Ausma von Tagesschlfrigkeit bei Patienten mit schlafbezogenen Atmungsstrungen zu erfassen. Ind Health. doi:10.1016/j.clinph.2006.03.011, Kapur VK, Baldwin CM, Resnick HE, Gottlieb DJ, Nieto FJ (2005) Sleepiness in patients with moderate to severe sleep-disordered breathing. Int J Environ Res Public Health. KSS ratings may be a useful proxy for EEG or behavioral indicators of sleepiness. To date, there is not a validated version of Karolinska Sleepiness Scale for Mexican population. Rev Port Pneumol 18(6):267271. An erratum to this article is available at https://doi.org/10.1007/s41105-017-0111-0. 2012;7(9):e45987. Original study: kerstedt, T. and Gillberg, M. Subjective and objective sleepiness in the active individual. Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden, Stress Research Institute, Stockholm University, Stockholm, Sweden, You can also search for this author in