Also learn why ingredients such as alpha-lipoic acid, soy, resveratrol, quercetin may impair thyroid function. Cureus. The study took place over 10 weeks, and participant results were assessed based on sleep onset latency, total sleep time, sleep efficiency, and wake after sleep onset. People who are pregnant or breastfeeding should avoid using the herb, as not enough is known about its safety. According to a December 2012 study in the Journal of Medicine and Life, SSRIs are primarily the recommended treatment for depression. View abstract. Withania somnifera (Indian ginseng) in diabetes mellitus: A systematic review and meta-analysis of scientific evidence from experimental research to clinical application. Change in balance, feeling shaky, or unsteady, Not able to think clearly or change in thinking, US Department of Defense Dietary Supplement Resource, https://www.opss.org/article/ashwagandha-dietary-supplement-products, This generalized information is a limited summary of diagnosis, treatment, and/or medication information. If you consume something that isn't recommended, you could end up reducing the effectiveness of your medication or increasing the likelihood of side effects. Some don't work well with prescription medicines. . Guerrero FA, Medina GM. Ashwagandha interacts with several types of prescription medicine, so consult your health care provider before taking this herbal remedy. The use of this information is governed by the Terms of Use, available at https://www.wolterskluwer.com/en/know/clinical-effectiveness-terms. View abstract. 2020;72:28-36. Ashwaganda is used to treat Herbal Supplementation. Indian J Physiol Pharmacol. Most reported drug interactions are based on the potential additive effectswhen combined with certain drugs (e.g. Ashwagandha Root (Withania somnifera): Analytical, quality control, and therapuetic monograph. View abstract. Front Pharmacol 2022;13:901710. OTHER NAME(S): Ajagandha, Amangura, Amukkirag, Asan, Asana, Asgan, Ashwagandha has most often been used by adults in doses up to 1000 mg daily, for up to 12 weeks. Twelve studies were included in the final review, and researchers concluded that ashwagandha showed more improvements in physical performance than placebo pills. 2012;10(1):48-49. ", Mayo Clinic: "Selective Serotonin Reuptake Inhibitors (SSRIs)", Cleveland Clinic: "Depression Medicines: Risks / Benefits", Shanghai Archives of Psychiatry: "Use of Antipsychotics in the Treatment of Depressive Disorders", Food and Drug Administration: "Vitamins and Minerals Chart", World Journal of Biological Chemistry: "Complexity of Vitamin E Metabolism", NCBI Bookshelf: "Depression in Adults With a Chronic Physical Health Problem: Treatment and Management", Journal of Medicine and Life: "Nutrition and Depression at the Forefront of Progress", Harvard Health Publishing: "Cytochrome P450 Enzymes and Psychiatric Drugs", Complementary Therapies in Medicine Journal: "Evaluation of the Efficacy of Withania Somnifera (Ashwagandha) Root Extract in Patients With Obsessive-Compulsive Disorder: A Randomized Double-Blind Placebo-Controlled Trial", Serotonin and norepinephrine reuptake inhibitors (SNRIs), Norepinephrine and dopamine reuptake inhibitors (NDRIs), Noncompetitive N-methyl-D-aspartate receptor antagonists. When taken inappropriately, ashwagandha can have side effects and potentially serious medicinal interactions. Does Ashwagandha interact with other medications? Find - Forest Raga View abstract. Pusec CM, Wolsky R, Llerena C, Sura P. A Case of Supplement-Induced Hepatitis. Ashwagandha is an evergreen shrub that grows in Asia and Africa. Does Ambien Cause Withdrawal Symptoms After Stopping? Be sure to tell your doctor that you take this product if you are scheduled for surgery or tests. Panda S, Kar A. Withania somnifera and Bauhinia purpurea in the regulation of circulating thyroid hormone concentrations in female mice. Most ashwagandha supplements are naturally vegan and gluten-free. 2021;51(4):363-365. Int Ayurvedic Med J 2013;1(5):1-7. J Ayurveda Integr Med. The most common side effects include: Other less common side effects of ashwagandha include: If you experience side effects when taking ashwagandha, be sure to stop using it and seek advice from a healthcare provider. The body naturally produces thyroid hormones. People with thyroid conditions or who are taking thyroid medications should talk with a healthcare provider before using ashwagandha. Take extra care if you are taking drugs to help with your thyroid. Studies on immunomodulatory activity of Withania somnifera (Ashwagandha) extracts in experimental immune inflammation. It is also recommended that people with hormone-sensitive prostate cancer avoid using ashwagandha due to possible hormone changes caused by the herb. Taking it with drugs that increase levels of thyroid hormone (e.g. View abstract. Some benzodiazepine drugs include alprazolam, known as the brand Xanax; clonazepam, known as Klonopin; diazepam, known as Valium; lorazepam, known as Ativan; and triazolam, known as Halcion. Which is why it might lead to sleepiness and drowsiness with medications such as Wellburtin. ; Vomiting and nausea. Dr. Brian Staiger also has herbalist training and educational certificates in the field of medical ethnobotany. Ashwagandha may have additive effects to certain drugs that are used for diabetes, high blood pressure, and low thyroid hormone, to name a few. 2020;40(4):825-829. It was concluded that participants from all five studies found improvements in their anxiety. Choudhary, M. I., Nawaz, S. A., ul-Haq, Z., Lodhi, M. A., Ghayur, M. N., Jalil, S., Riaz, N., Yousuf, S., Malik, A., Gilani, A. H., and ur-Rahman, A. Withanolides, a new class of natural cholinesterase inhibitors with calcium antagonistic properties. of signs you need emergency medical attention or call 911. Sharma AK, Basu I, Singh S. Efficacy and safety of Ashwagandha root extract in subclinical hypothyroid patients: a double-blind, randomized placebo-controlled trial. If you are experiencing serious medical symptoms, please see the Herbal supplements and heart medicines may not mix - Mayo Clinic Efficacy and safety evaluation of ayurvedic treatment (ashwagandha powder and sidh makardhwaj) in rheumatoid arthritis patients: a pilot perspective study. . Although side effects do not always occur, you may experience drowsiness, stomach pain, or loose stools when taking ashwagandha. Skinmed. Notably, ashwagandha doses typically do not exceed 1,000 milligrams per day for up to 12 weeks. Phase III randomized clinical trial of BV-4051, an Ayurvedic polyherbal formulation in moderate SARS-CoV-2 infections and its impact on inflammatory biomarkers. Effect of an ashwagandha (Withania Somnifera) root extract on climacteric symptoms in women during perimenopause: A randomized, double-blind, placebo-controlled study. View abstract. Skinmed. Lousewort - Amiloride, Hydrochlorothiazide, Cassia Cinnamon - Aspirin, Butalbital, Caffeine, Abuta - Bismuth Subcarbonate, Calcium Carbonate, Opium, English Adder's Tongue - Inotuzumab Ozogamicin, Patricia Kane (pk) Protocol - Indomethacin, Pulsed Electromagnetic Field (pemf) Therapy - Cabozantinib. J Ethnopharmacol 1999;67:233-39. Ashwagandha can react with certain medications and supplements you may already take, and result in adverse effects. View abstract. For this reason, it's always best to tell a healthcare provider if you are taking any medications and/or supplements before starting a new supplement. According to an August 2016 study in the Complementary Therapies in Medicine Journal, taking ashwagandha with antidepressants like SSRIs can be a safe, effective and healthy way of supporting your mental health. Ghosal S, Lal J, Srivastava R, and et al. J Funct Morphol Kinesiol. In general, Ashwagandha is thought to be safe when used in moderate amounts. Ashwagandha has mild interactions with at least 29 different drugs. root extract in improving cardiorespiratory endurance and recovery in healthy athletic adults. View abstract. Integr Cancer Ther. By Brittany Lubeck, RD low blood sugar). No, that's not true all the time. It should not be confused with Physalis alkekengi, which is also referred to as winter cherry. Bjrnsson HK, Bjrnsson ES, Avula B, et al. Supplement use should be individualized and vetted by a healthcare professional, such as a registered dietitian, pharmacist, or healthcare provider. This product can contain high amounts of iron. After 60 days, participants who took ashwagandha reported lower levels of stress and were also found to have reduced cortisol levels. 2012;34(3):255-62. Ashwagandha: Supplement, Uses, Side Effects, Dosages, Interactions Ashwagandha has not been well studied in regard to potential interactions with prescription medication. Safety studies have not been performed on these populations, so it's best to avoid using ashwagandha altogether while pregnant or breastfeeding. Ashwagandha: ADHD Uses, Warnings, Side Effects, Dosage - MedicineNet Some of the more compelling potential uses of ashwagandha are outlined below. Ashwagandha is purported as useful for relieving stress, fatigue, pain and gastrointestinal problems, and treating diabetes, rheumatoid arthritis and epilepsy. Changes in thyroid hormone concentrations after administration of ashwagandha root extract to adult male mice. It does NOT include all information about conditions, treatments, medications, side effects, or risks that may apply to a specific patient. One study, published in Phytotherapy Research, reported that ashwagandha supplementation reduced blood sugar and A1c levels, although this was a relatively small study. Biswal BM, Sulaiman SA, Ismail HC, Zakaria H, Musa KI. These are: In addition to these commonly prescribed antidepressants, there are other central nervous system drugs with antidepressant effects, like antipsychotics, as well as herbs and supplements that have natural antidepressant properties. 2004;42(12):2015-2020. 2021;57:102642. doi:10.1016/j.ctim.2020.102642, Bjrnsson HK, Bjrnsson ES, Avula B, et al. Ambiye VR, Langade D, Dongre S, Aptikar P, Kulkarni M, Dongre A. However, certain vitamins, supplements and medications are processed via the same enzymatic pathway (cytochrome P450) as your antidepressants. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. doi:10.7759/cureus.6466, Lopresti AL, Smith SJ, Malvi H, Kodgule R. An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: a randomized, double-blind, placebo-controlled study. It may also interact with other herbs, supplements, and even foods. Sleep Med. According to an April 2016 review in the Journal of Psychiatry, several nutrients are involved in healthy brain activity. Pharmacological evaluation of ashwagandha highlighting its healthcare claims, safety, and toxicity aspects. Does Ashwagandha Interact With Prescription Drugs? 2021;6(1):20. doi:10.3390/jfmk6010020, Langade D, Kanchi S, Salve J, Debnath K, Ambegaokar D. Efficacy and safety of ashwagandha (Withania somnifera) root extract in insomnia and anxiety: a double-blind, randomized, placebo-controlled study. Tohda, C. [Overcoming several neurodegenerative diseases by traditional medicines: the development of therapeutic medicines and unraveling pathophysiological mechanisms]. Data sources include IBM Watson Micromedex (updated 2 Apr 2023), Cerner Multum (updated 17 Apr 2023), ASHP (updated 10 Apr 2023) and others. When you visit the site, Dotdash Meredith and its partners may store or retrieve information on your browser, mostly in the form of cookies. 2021;2:72-81. doi:10.1016/j.crtox.2021.02.002. You can also use ashwagandha as an herbal tea. If possible, choose an ashwagandha supplement that has been reviewed and approved by a third-party agency, like USP, NSF International, or ConsumerLab. Does Synthroid interact with supplements that may help with arthritis, such as ashwagandha, collagen, or turmeric? Medically reviewed by Drugs.com. Among the five cases, ashwagandha dosing ranged from 450 to 1,350 milligrams daily. View abstract. Indian J Exp Biol. View abstract. Acta Oncol. Salve J, Pate S, Debnath K, Langade D. Adaptogenic and anxiolytic effects of ashwagandha root extract in healthy adults: A double-blind, randomized, placebo-controlled clinical study. J Res Ayur Sid 1980;1:370-385. However, many studies supporting the use of ashwagandha are small or poorly designed. Chengappa KN, Bowie CR, Schlicht PJ, Fleet D, Brar JS, Jindal R. Randomized placebo-controlled adjunctive study of an extract of withania somnifera for cognitive dysfunction in bipolar disorder. 2021;45(1):176. doi:10.1186/s42269-021-00635-6, White PT, Subramanian C, Motiwala HF, Cohen MS. Natural withanolides in the treatment of chronic diseases. Taking high doses of ashwagandha may increase your risk of side effects. Bhattacharya, S. K. and Muruganandam, A. V. Adaptogenic activity of Withania somnifera: an experimental study using a rat model of chronic stress. Ashwagandha might cause sleepiness and slowed breathing. ashwaganda: Dosing, contraindications, side effects, and - Epocrates J Neurol Sci 2000;176:124-7. View abstract. Ashwagandha can also interact with some medications and affect how they work. Nat.Prod.Res 2005;19(6):567-571. Ultimately, the supplements and foods you can . Therapeutic Research Faculty 2020. Lu, L., Liu, Y., Zhu, W., Shi, J., Liu, Y., Ling, W., and Kosten, T. R. Traditional medicine in the treatment of drug addiction. 2013;45(4):417-8. It is recommended that people with hormone-sensitive prostate cancer avoid using ashwagandha out of an abundance of caution. 1988;26(11):877-882. Some other sedative medications include clonazepam (Klonopin), lorazepam (Ativan), phenobarbital (Donnatal), zolpidem (Ambien), and others. Taking ashwagandha with thyroid hormone pills might cause too much thyroid hormone in the body, and increase the effects and side effects of thyroid hormone. This information may not fit your specific health circumstances. Therefore, it is important to talk to your healthcare provider about any supplements you plan to take and check in about potential interactions with other supplements or medications.